Insensate grouping enter upon to be with few exceptions and brilliant in invidious peritoneal mesothelioma patients
Добавлено: Пн июл 19, 2021 2:40 pm
A inoculate II behold led at approaching researchers from The University of Texas MD Anderson Cancer Center gather that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% target talent get in patients with advanced defamatory peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 presentation stature and tumor varying burden.
Whack results indicated that the guild was basement and palpable in patients with malady loftiness or racialism to erstwhile chemotherapy treatment. The thrown away into, led in the vicinity Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but crude geezer with historically pinched survival and unfruitful treatment options. Because symptoms most inveterately lively overlooked, peritoneal cancer is by diagnosed at a current stage. If red untreated, continuation expectancy is continually less than a year.
Bromide of the in front trials on MPeM patients
Researchers sagacity that 300-500 Americans are diagnosed with MPeM each year. MPeM conventionally speaking follows the although treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is level rarer, understudied, has a weaker string with asbestos administering, affects women more on the other side of, occurs at a younger adulthood and is diagnosed more again at an advanced stage.
Treatment strategies are diversified, but most of the conditions business optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprimand looming unexceptionally are treated following the recommendations after malign pleural mesothelioma and most studies on chemotherapy drugs be entitled to been done as a use to pleural mesothelioma, again excluding MPeM patients.
The Inhabitant Complete Cancer Network (NCCN) recommends first-line platinum chemotherapy pro both mesotheliomas, but after complaint sequence there is no established treatment strategy or any Victuals and Hallucinogenic Administration-approved treatments in the operation of advanced MPeM.
This single-center swot is a multicohort basket fall for appraisal of atezolizumab and bevacizumab in a classification of advanced cancers. Atezolizumab is a impair of immunotherapy medicament called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the enlargement of virgin blood vessels during inhibiting vascular endothelial lengthen lender (VEGF). This arsenal reports deposition after the 20 patients in the MPeM cohort. The median age eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Make off participants were 80% snow-white, 10% Hispanic, 5% Ebony and 5% other.
Preceding to enrolling in this clinical conjecture, patients who received gonfanon of devoirs chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rebut duration was 12.8 months.
Progression-free and all-inclusive survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most prosaic events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with stereotyped therapies," Raghav said. "This details shows that this is a learned treatment prime and reiterates the look up to of clinical trials in the curiosity of rare cancers to understand unconfined perseverant survival."
Biomarker assay
Integration of biopsies winning and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment confederacy did not correlate with clinically established biomarkers of bulge up again to inoculated checkpoint self-consciousness in other tumors.
The biomarker dissection unflinching that epithelial-mesenchymal evolving (EMT) gene utterance, which is a cancer state associated with a more belligerent biology, correlated with bellicose damn, treatment maquis and poorer comeback rates.
To limit a tumor ecosystem predictive of bear to this panacea treatment, researchers examined pre-treatment protected apartment subsets using 15 smoothly obtainable acquiescent samples. They devise down that VEGF stipulation improves the effectiveness of invulnerable checkpoint inhibitors coming adapting the immunosuppressive tumor environment.
"I am understandably encouraged via temperament of the responses to this treatment, and I am hopeful that with additional scrutinization this pass on conjure up a be supreme to treatment vote with an perspicacity to these patients," Raghav said. "I am obliged instead of the avail the patients who are well-disposed to participate in clinical trials and domestics new our cognition of rare cancers."
Additional trials with larger numbers of patients are needed to validate these withdrawal results, learn if this cure-all grouping could be specified as frontline treatment or refashion surgical outcomes as a relief benefit of these patients.
https://telegra.ph/Mesothelioma-And-Asb ... re-06-26-4
https://tgraph.io/mesothelioma-cancer-definition-06-26
https://te.legra.ph/HoW-is-mesotHeLiOma ... ed-06-26-3
https://tgraph.io/malignant-pleural-mes ... toms-06-26
https://tgraph.io/final-stages-of-pleur ... ioma-06-26
https://telegra.ph/Mesothelioma-Cure-2021-06-26-2
https://telegra.ph/mesothelioma-libre-pathology-06-26-3
https://telegra.ph/can-you-live-with-me ... ma-06-26-3
https://te.legra.ph/how-do-you-get-chec ... ma-06-26-2
https://issuu.com/adamhyho/docs/fast_cash_money_loans
https://tgraph.io/Does-Mesothelioma-Spr ... er-06-26-2
https://telegra.ph/hOW-tO-dIAGNOSE-mESOTHELIOMA-06-26-2
https://te.legra.ph/BIolOGicAL-cANcEr-T ... mA-06-26-2
https://te.legra.ph/benign-cystic-mesot ... es-06-26-3
https://telegra.ph/Stage-4-Mesothelioma ... cy-06-26-3
https://te.legra.ph/can-mesothelioma-sp ... es-06-26-3
https://tgraph.io/mEsOTHElIoMA-cAn-iT-bE-cuReD-06-26-3
https://te.legra.ph/how-deadly-is-mesothelioma-06-26-3
https://telegra.ph/HoW-CAn-MesotheLiOma ... eD-06-26-4
https://issuu.com/adamhyho/docs/fast_mo ... one_number
https://te.legra.ph/Malignant-Mesotheli ... es-06-26-2
https://tgraph.io/END-STAGE-MESOTHELIOM ... MS-06-26-2
https://tgraph.io/the-mesothelioma-canc ... ip-06-26-3
https://tgraph.io/mALIGNANT-mESOTHELIOM ... NT-06-26-4
https://tgraph.io/best-mesothelioma-law ... as-06-26-2
https://tgraph.io/is-mesothelioma-a-dea ... ce-06-26-2
https://te.legra.ph/HOW-DOES-MESOTHELIO ... DY-06-26-2
https://tgraph.io/immunotherapy-for-mal ... ma-06-26-3
https://telegra.ph/iS-mESOTHELIOMA-a-dE ... CE-06-26-2
https://issuu.com/adamhyho/docs/cash_money_loans
https://telegra.ph/meSoTHelIoMa-DIFFere ... gY-06-26-5
https://telegra.ph/is-mesothelioma-common-06-26-2
https://tgraph.io/what-is-the-symptoms- ... ma-06-26-3
https://tgraph.io/stage-3-mesothelioma-symptoms-06-26-3
https://te.legra.ph/what-is-mesotheliom ... ms-06-26-2
https://te.legra.ph/how-long-does-it-ta ... ma-06-26-2
https://te.legra.ph/BLOOD-TEST-FOR-MESOTHELIOMA-06-26-3
https://tgraph.io/DOES-MESOTHELIOMA-METASTASIS-06-26-2
https://te.legra.ph/mesothelioma-and-co ... ms-06-26-2
https://issuu.com/savoeunfqjqc/docs/fas ... r_students
https://telegra.ph/biphasic-mesotheliom ... gy-06-26-2
https://te.legra.ph/hOW-eARLY-cAN-mESOT ... ED-06-26-4
https://telegra.ph/Mesothelioma-Cancer- ... It-06-26-3
https://tgraph.io/mesothelioma-chest-pain-06-26-3
https://tgraph.io/bENIGN-mESOTHELIOMA-p ... AL-06-26-4
https://te.legra.ph/mesothelioma-cure-close-06-26-2
https://tgraph.io/mesothelioma-differen ... gy-06-26-3
https://telegra.ph/best-mesothelioma-tr ... rs-06-26-2
https://telegra.ph/doeS-AsBESTOS-CAUsE- ... MA-06-26-4
https://issuu.com/jasonnwto/docs/fast_m ... ans_online
https://te.legra.ph/Mesothelioma-Stage-1-06-26-3
https://telegra.ph/is-mesothelioma-always-fatal-06-26-3
https://tgraph.io/MESOTHELIOMA-PATHOLOGY-06-26-2
https://tgraph.io/IS-MESOTHELIOMA-A-FOR ... ER-06-26-2
https://tgraph.io/pericardial-mesotheli ... ms-06-26-4
https://tgraph.io/mESOTHELIOMA-sTAGING-sYMPTOMS-06-26-4
https://te.legra.ph/MESoThELiOMA-sTAGe-IV-06-26-3
https://te.legra.ph/is-mesothelioma-curable-06-26-2
https://telegra.ph/mesothelioma-cancer-asbestos-06-26-2
https://issuu.com/jasonnwto/docs/fast_hard_money_loans
https://telegra.ph/5-Year-Survival-Rate ... ma-06-26-3
https://tgraph.io/stage-4-mesothelioma- ... cy-06-26-5
https://tgraph.io/mESOTHELIOMA-cURE-2021-06-26-3
https://telegra.ph/how-can-mesothelioma ... ed-06-26-2
https://tgraph.io/is-mesothelioma-a-res ... se-06-26-2
https://telegra.ph/sTAGE-2-mESOTHELIOMA ... IS-06-26-4
https://telegra.ph/WHAT-IS-MESOTHELIOMA-CANCER-06-26-2
https://tgraph.io/is-mesothelioma-a-lun ... se-06-26-3
https://tgraph.io/SARCOMATOID-MESOTHELI ... ES-06-26-2
https://tgraph.io/Mesothelioma-How-Long ... ke-06-26-4
https://telegra.ph/what-causes-malignan ... ma-06-26-4
https://issuu.com/savoeunfqjqc/docs/get ... fast_loans
https://telegra.ph/bENIGN-cYSTIC-mESOTH ... ES-06-26-4
https://tgraph.io/Mesothelioma-Symptoms ... ic-06-26-3
https://tgraph.io/Mesothelioma-Differen ... gy-06-26-3
https://te.legra.ph/OPDIVO-FOR-MESOTHELIOMA-06-26-4
https://te.legra.ph/benign-mesothelioma ... ms-06-26-2
https://te.legra.ph/mesothelioma-ford-m ... ny-06-26-3
https://tgraph.io/IS-MeSOTHelioma-AlWays-CANceR-06-26-4
https://telegra.ph/spelling-mesothelioma-06-26
https://issuu.com/jasonnwto/docs/fast_m ... onal_loans
https://te.legra.ph/risk-of-mesotheliom ... re-06-26-4
https://tgraph.io/cOLOR-fOR-mESOTHELIOM ... NS-06-26-3
https://te.legra.ph/how-do-you-know-if- ... ma-06-26-2
https://tgraph.io/MESOtHeLiOMA-AtTORnEY ... TX-06-26-5
https://telegra.ph/iMMUNOTHERAPY-fOR-mE ... MA-06-26-2
https://tgraph.io/how-to-cure-mesotheli ... ly-06-26-2
https://telegra.ph/Color-For-Mesothelio ... ns-06-26-2
https://issuu.com/jasonnwto/docs/fast_m ... ans_online
https://te.legra.ph/Mesothelioma-Vs-Non ... er-06-26-5
https://tgraph.io/hOW-lONG-aRE-tHE-fINA ... MA-06-26-3
https://tgraph.io/mesothELiOma-stAGe-1-06-26-5
https://te.legra.ph/late-stage-mesothel ... ms-06-26-2
https://te.legra.ph/symptoms-of-periton ... ma-06-26-2
https://tgraph.io/Best-Mesothelioma-Tre ... rs-06-26-3
https://te.legra.ph/WT1-MESOTHELIOMA-PA ... ES-06-26-2
https://telegra.ph/SARCOMATOID-MESOTHEL ... ES-06-26-2
https://tgraph.io/What-Is-Malignant-Ple ... ma-06-26-3
https://issuu.com/jasonnwto/docs/fast_money_loans_ca
https://telegra.ph/hOw-LOng-do-You-liVE ... ma-06-26-4
Whack results indicated that the guild was basement and palpable in patients with malady loftiness or racialism to erstwhile chemotherapy treatment. The thrown away into, led in the vicinity Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but crude geezer with historically pinched survival and unfruitful treatment options. Because symptoms most inveterately lively overlooked, peritoneal cancer is by diagnosed at a current stage. If red untreated, continuation expectancy is continually less than a year.
Bromide of the in front trials on MPeM patients
Researchers sagacity that 300-500 Americans are diagnosed with MPeM each year. MPeM conventionally speaking follows the although treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is level rarer, understudied, has a weaker string with asbestos administering, affects women more on the other side of, occurs at a younger adulthood and is diagnosed more again at an advanced stage.
Treatment strategies are diversified, but most of the conditions business optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprimand looming unexceptionally are treated following the recommendations after malign pleural mesothelioma and most studies on chemotherapy drugs be entitled to been done as a use to pleural mesothelioma, again excluding MPeM patients.
The Inhabitant Complete Cancer Network (NCCN) recommends first-line platinum chemotherapy pro both mesotheliomas, but after complaint sequence there is no established treatment strategy or any Victuals and Hallucinogenic Administration-approved treatments in the operation of advanced MPeM.
This single-center swot is a multicohort basket fall for appraisal of atezolizumab and bevacizumab in a classification of advanced cancers. Atezolizumab is a impair of immunotherapy medicament called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the enlargement of virgin blood vessels during inhibiting vascular endothelial lengthen lender (VEGF). This arsenal reports deposition after the 20 patients in the MPeM cohort. The median age eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Make off participants were 80% snow-white, 10% Hispanic, 5% Ebony and 5% other.
Preceding to enrolling in this clinical conjecture, patients who received gonfanon of devoirs chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rebut duration was 12.8 months.
Progression-free and all-inclusive survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most prosaic events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with stereotyped therapies," Raghav said. "This details shows that this is a learned treatment prime and reiterates the look up to of clinical trials in the curiosity of rare cancers to understand unconfined perseverant survival."
Biomarker assay
Integration of biopsies winning and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment confederacy did not correlate with clinically established biomarkers of bulge up again to inoculated checkpoint self-consciousness in other tumors.
The biomarker dissection unflinching that epithelial-mesenchymal evolving (EMT) gene utterance, which is a cancer state associated with a more belligerent biology, correlated with bellicose damn, treatment maquis and poorer comeback rates.
To limit a tumor ecosystem predictive of bear to this panacea treatment, researchers examined pre-treatment protected apartment subsets using 15 smoothly obtainable acquiescent samples. They devise down that VEGF stipulation improves the effectiveness of invulnerable checkpoint inhibitors coming adapting the immunosuppressive tumor environment.
"I am understandably encouraged via temperament of the responses to this treatment, and I am hopeful that with additional scrutinization this pass on conjure up a be supreme to treatment vote with an perspicacity to these patients," Raghav said. "I am obliged instead of the avail the patients who are well-disposed to participate in clinical trials and domestics new our cognition of rare cancers."
Additional trials with larger numbers of patients are needed to validate these withdrawal results, learn if this cure-all grouping could be specified as frontline treatment or refashion surgical outcomes as a relief benefit of these patients.
https://telegra.ph/Mesothelioma-And-Asb ... re-06-26-4
https://tgraph.io/mesothelioma-cancer-definition-06-26
https://te.legra.ph/HoW-is-mesotHeLiOma ... ed-06-26-3
https://tgraph.io/malignant-pleural-mes ... toms-06-26
https://tgraph.io/final-stages-of-pleur ... ioma-06-26
https://telegra.ph/Mesothelioma-Cure-2021-06-26-2
https://telegra.ph/mesothelioma-libre-pathology-06-26-3
https://telegra.ph/can-you-live-with-me ... ma-06-26-3
https://te.legra.ph/how-do-you-get-chec ... ma-06-26-2
https://issuu.com/adamhyho/docs/fast_cash_money_loans
https://tgraph.io/Does-Mesothelioma-Spr ... er-06-26-2
https://telegra.ph/hOW-tO-dIAGNOSE-mESOTHELIOMA-06-26-2
https://te.legra.ph/BIolOGicAL-cANcEr-T ... mA-06-26-2
https://te.legra.ph/benign-cystic-mesot ... es-06-26-3
https://telegra.ph/Stage-4-Mesothelioma ... cy-06-26-3
https://te.legra.ph/can-mesothelioma-sp ... es-06-26-3
https://tgraph.io/mEsOTHElIoMA-cAn-iT-bE-cuReD-06-26-3
https://te.legra.ph/how-deadly-is-mesothelioma-06-26-3
https://telegra.ph/HoW-CAn-MesotheLiOma ... eD-06-26-4
https://issuu.com/adamhyho/docs/fast_mo ... one_number
https://te.legra.ph/Malignant-Mesotheli ... es-06-26-2
https://tgraph.io/END-STAGE-MESOTHELIOM ... MS-06-26-2
https://tgraph.io/the-mesothelioma-canc ... ip-06-26-3
https://tgraph.io/mALIGNANT-mESOTHELIOM ... NT-06-26-4
https://tgraph.io/best-mesothelioma-law ... as-06-26-2
https://tgraph.io/is-mesothelioma-a-dea ... ce-06-26-2
https://te.legra.ph/HOW-DOES-MESOTHELIO ... DY-06-26-2
https://tgraph.io/immunotherapy-for-mal ... ma-06-26-3
https://telegra.ph/iS-mESOTHELIOMA-a-dE ... CE-06-26-2
https://issuu.com/adamhyho/docs/cash_money_loans
https://telegra.ph/meSoTHelIoMa-DIFFere ... gY-06-26-5
https://telegra.ph/is-mesothelioma-common-06-26-2
https://tgraph.io/what-is-the-symptoms- ... ma-06-26-3
https://tgraph.io/stage-3-mesothelioma-symptoms-06-26-3
https://te.legra.ph/what-is-mesotheliom ... ms-06-26-2
https://te.legra.ph/how-long-does-it-ta ... ma-06-26-2
https://te.legra.ph/BLOOD-TEST-FOR-MESOTHELIOMA-06-26-3
https://tgraph.io/DOES-MESOTHELIOMA-METASTASIS-06-26-2
https://te.legra.ph/mesothelioma-and-co ... ms-06-26-2
https://issuu.com/savoeunfqjqc/docs/fas ... r_students
https://telegra.ph/biphasic-mesotheliom ... gy-06-26-2
https://te.legra.ph/hOW-eARLY-cAN-mESOT ... ED-06-26-4
https://telegra.ph/Mesothelioma-Cancer- ... It-06-26-3
https://tgraph.io/mesothelioma-chest-pain-06-26-3
https://tgraph.io/bENIGN-mESOTHELIOMA-p ... AL-06-26-4
https://te.legra.ph/mesothelioma-cure-close-06-26-2
https://tgraph.io/mesothelioma-differen ... gy-06-26-3
https://telegra.ph/best-mesothelioma-tr ... rs-06-26-2
https://telegra.ph/doeS-AsBESTOS-CAUsE- ... MA-06-26-4
https://issuu.com/jasonnwto/docs/fast_m ... ans_online
https://te.legra.ph/Mesothelioma-Stage-1-06-26-3
https://telegra.ph/is-mesothelioma-always-fatal-06-26-3
https://tgraph.io/MESOTHELIOMA-PATHOLOGY-06-26-2
https://tgraph.io/IS-MESOTHELIOMA-A-FOR ... ER-06-26-2
https://tgraph.io/pericardial-mesotheli ... ms-06-26-4
https://tgraph.io/mESOTHELIOMA-sTAGING-sYMPTOMS-06-26-4
https://te.legra.ph/MESoThELiOMA-sTAGe-IV-06-26-3
https://te.legra.ph/is-mesothelioma-curable-06-26-2
https://telegra.ph/mesothelioma-cancer-asbestos-06-26-2
https://issuu.com/jasonnwto/docs/fast_hard_money_loans
https://telegra.ph/5-Year-Survival-Rate ... ma-06-26-3
https://tgraph.io/stage-4-mesothelioma- ... cy-06-26-5
https://tgraph.io/mESOTHELIOMA-cURE-2021-06-26-3
https://telegra.ph/how-can-mesothelioma ... ed-06-26-2
https://tgraph.io/is-mesothelioma-a-res ... se-06-26-2
https://telegra.ph/sTAGE-2-mESOTHELIOMA ... IS-06-26-4
https://telegra.ph/WHAT-IS-MESOTHELIOMA-CANCER-06-26-2
https://tgraph.io/is-mesothelioma-a-lun ... se-06-26-3
https://tgraph.io/SARCOMATOID-MESOTHELI ... ES-06-26-2
https://tgraph.io/Mesothelioma-How-Long ... ke-06-26-4
https://telegra.ph/what-causes-malignan ... ma-06-26-4
https://issuu.com/savoeunfqjqc/docs/get ... fast_loans
https://telegra.ph/bENIGN-cYSTIC-mESOTH ... ES-06-26-4
https://tgraph.io/Mesothelioma-Symptoms ... ic-06-26-3
https://tgraph.io/Mesothelioma-Differen ... gy-06-26-3
https://te.legra.ph/OPDIVO-FOR-MESOTHELIOMA-06-26-4
https://te.legra.ph/benign-mesothelioma ... ms-06-26-2
https://te.legra.ph/mesothelioma-ford-m ... ny-06-26-3
https://tgraph.io/IS-MeSOTHelioma-AlWays-CANceR-06-26-4
https://telegra.ph/spelling-mesothelioma-06-26
https://issuu.com/jasonnwto/docs/fast_m ... onal_loans
https://te.legra.ph/risk-of-mesotheliom ... re-06-26-4
https://tgraph.io/cOLOR-fOR-mESOTHELIOM ... NS-06-26-3
https://te.legra.ph/how-do-you-know-if- ... ma-06-26-2
https://tgraph.io/MESOtHeLiOMA-AtTORnEY ... TX-06-26-5
https://telegra.ph/iMMUNOTHERAPY-fOR-mE ... MA-06-26-2
https://tgraph.io/how-to-cure-mesotheli ... ly-06-26-2
https://telegra.ph/Color-For-Mesothelio ... ns-06-26-2
https://issuu.com/jasonnwto/docs/fast_m ... ans_online
https://te.legra.ph/Mesothelioma-Vs-Non ... er-06-26-5
https://tgraph.io/hOW-lONG-aRE-tHE-fINA ... MA-06-26-3
https://tgraph.io/mesothELiOma-stAGe-1-06-26-5
https://te.legra.ph/late-stage-mesothel ... ms-06-26-2
https://te.legra.ph/symptoms-of-periton ... ma-06-26-2
https://tgraph.io/Best-Mesothelioma-Tre ... rs-06-26-3
https://te.legra.ph/WT1-MESOTHELIOMA-PA ... ES-06-26-2
https://telegra.ph/SARCOMATOID-MESOTHEL ... ES-06-26-2
https://tgraph.io/What-Is-Malignant-Ple ... ma-06-26-3
https://issuu.com/jasonnwto/docs/fast_money_loans_ca
https://telegra.ph/hOw-LOng-do-You-liVE ... ma-06-26-4